Marijuana and psychosis

This was in today’s Economist newsletter, and I’ve seen it elsewhere too.  Scary!  But then again, what is the definition of psychosis?

Isn’t getting your thought and emotions so impaired that you lose contact with external reality the point of high THC content marijuana?  Is this a feature not a bug?  External reality can be rough.

The study, in The Lancet, used the ICD-10 Criteria (F20-33), so schizophrenia and manic/bipolar episodes. The study compared people hospitalized for that kind of thing versus a control general population. Here’s how the study worked:

We included patients aged 18–64 years who presented to psychiatric services in 11 sites across Europe and Brazil with first-episode psychosis and recruited controls representative of the local populations.

Then this part:

We applied adjusted logistic regression models to the data to estimate which patterns of cannabis use carried the highest odds for psychotic disorder. Using Europe-wide and national data on the expected concentration of Δ9-tetrahydrocannabinol (THC) in the different types of cannabis available across the sites, we divided the types of cannabis used by participants into two categories: low potency (THC <10%) and high potency (THC ≥10%). Assuming causality, we calculated the population attributable fractions (PAFs) for the patterns of cannabis use associated with the highest odds of psychosis and the correlation between such patterns and the incidence rates for psychotic disorder across the study sites.

“expected” and “assuming” are two words that do a lot of work here, but I don’t have time to read the whole study, I have to write cartoons.

In my neighborhood the most booming new shops sell either marijuana or cold brew coffee.  Personally I wonder if drinking huge amounts of highly caffeinated cold brew might be more crazy-making than marijuana.

There is certainly ample psychosis in Los Angeles, so much so that it might be necessary to induce mild psychosis just so you can understand what’s going on with everybody.  The chicken and egg, correlation and causation on psychosis / drug use is a tough one to unravel, as the study’s authors acknowledge.  The study also notes that patients presenting with psychosis were more likely to have smoked ten or more cigarettes a day.

 


Proust’s coffee

Although fifteen years later [Marcel Proust] would recall his year as a soldier with total delight, as “a paradise,” at the time he complained bitterly and his mother had to write him consoling, babying letters, telling him to think of the twelve months as twelve chocolate squares.

Imagine the guys in the barracks finding your letters from your mom telling you to think about your year as twelve chocolate squares.

In his short biography of Custer, Larry McMurtry mentions a few other short biographies he judges fine, including with a characteristic lack of false modesty his own biography of Crazy Horse, and this Edmund White biography of Proust.

So, I got it and read it.  Wonderful act of compression.  Thoughtful, succinct, at times funny, human, gentle, this book is a great guide to the man and artist, what his work meant and what he was after.

Thought this was wild:

In 1911 Proust became a subscriber to Théàtrophone, a service that held a telephone receiver up at a concert, which allowed people to stay at home and hear live music on their receivers.

The few hundred pages of Remembrance of Things Past I was supposed to read in college (“Proust, Joyce and Modernism”: a class I chose to take!) were tough going for me.  Proust won’t be hurried.  This guy didn’t even get a job  until he was in his thirties.  This was an unpaid job, as a librarian, and eventually he got fired for being out sick too much.  Proust is not interested in going at anyone’s pace except the languid pace of a man lying in bed, leisurely following the meandering paths of his own memory.

Proust always claimed that he had a bad memory and that, besides, a carefully reconstructed recollection, prompted by photos or shared reminiscences, was invariably colorless, Only an involuntary memory, triggered by a taste or smell or other sensation, could erase the passage of time and restore a past experience in its first, full effulgence.

Proust’s world was pretentious and can seem ridiculous.  Proust himself was a great mimic, reducing people to fits of laughter with his impressions.  He loved collecting anecdotes and gossip, grilling waiters for details (Proust was an extravagant tipper.)  White says that Georg D. Painter’s Marcel Proust: A Biography, the one-volume edition, is

so amusing that it could be used as a source for a stand-up comic.

I’ll be looking into this claim.

How about Proust’s maid, Céleste?

Céleste’s great anxiety was Proust’s morning (or afternoon) coffee.  It had to be ready the moment he rang for it, but the preparation took at least half an hour, since he liked the water to be dripped, drop by drop, through the grounds in order to produce the thickest, strongest possible “essence” of coffee.  Nor could he bear for it to be reheated…

This is after Céleste had been standing up for hours listening to Proust recount gossip he’d collected on “rare midnight sorties,” Proust waiting til midnight to go out because he was so afraid of dust.  Well, White tells us we read Proust because he knows that

only the gnarled knowledge that suffering brings us is of any real use.

Maybe Céleste pondered that while she remade the coffee.

Leaving the house was a challenge for Proust, but near the end of his life he made an outing to see Vermeer’s View of Delft:

On the night before he died Proust dictated a last sentence: “There is a Chinese patience in Vermeer’s craft.”

White tells us.  Man Ray took a picture of Proust right after the author died, you can see it here if you’re so inclined.  I’m told by the Met that Cocteau wrote of the scene:

Those who have seen this profile of calm, of order, of plenitude, will never forget the spectacle of an unbelievable recording device come to a stop, becoming an art object: a masterpiece of repose next to a heap of notebooks where our friend’s genius continues to live on like the wristwatch of a dead soldier.

True despair hours: